The DPH2 Polyclonal Antibody (CAB17475) is a valuable tool for researchers studying DPH2, a protein involved in mRNA processing and ribosome biogenesis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the DPH2 protein, this antibody enables the detection and analysis of DPH2 in a variety of cell types, making it an excellent choice for studies in molecular biology and cancer research.DPH2 is a key player in the process of diphthamide biosynthesis, which is essential for the function of eukaryotic ribosomes. Dysregulation of DPH2 has been linked to various diseases, including cancer.
By investigating the role of DPH2 in these conditions, researchers can gain valuable insights into the mechanisms underlying disease development and potentially identify novel therapeutic targets.Overall, the DPH2 Polyclonal Antibody is a reliable tool for researchers seeking to explore the function and regulation of DPH2 in both normal and disease states. Its high specificity and sensitivity make it an indispensable asset for advancing our understanding of the molecular pathways involved in mRNA processing and ribosome biogenesis.
Product Name:
DPH2 Rabbit Polyclonal Antibody
SKU:
CAB17475
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-330 of human DPH2 (NP_001375.2).
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1802
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse thymus, using DPH2 Rabbit pAb (CAB17475) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 300s.
