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Dopamine beta Hydroxylase Monoclonal Antibody (CAB23579)

SKU:
CAB23579
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $635
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Dopamine beta Hydroxylase Monoclonal Antibody
SKU:CAB23579
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human Dopamine beta Hydroxylase (NP_000778.3).
Sequence:LVVL WTDG DTAY FADA WSDQ KGQI HLDP QQDY QLLQ VQRT PEGL TLLF KRPF GTCD PKDY LIED GTVH LVYG ILEE PFRS LEAI NGSG LQMG LQRV QLLK PNIP EPEL PSDA CTME VQAP NIQI PSQE TTYW CYIK ELPK GFSR HHII KYE
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:DBM; ORTHYP1; Dopamine beta Hydroxylase
Positive Sample:SH-SY5Y
Conjugate:Unconjugated
Cellular Localization:Cytoplasmic vesicle, Single-pass type II membrane protein, chromaffin granule lumen, chromaffin granule membrane, secretory vesicle, secretory vesicle lumen, secretory vesicle membrane.
Calculated MW:69kDa
Observed MW:75-80kDa

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.

Purification Method:Affinity purification
Gene ID:1621
Clone Number:ARC3095
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from SH-SY5Y cells, using Dopamine beta Hydroxylase Rabbit mAb (CAB23579) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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