The Dopamine Beta Hydroxylase Monoclonal Antibody is a valuable tool for researchers studying the enzyme dopamine beta-hydroxylase (DBH), which is involved in the conversion of dopamine to norepinephrine. This antibody, produced from mouse monoclonal cells, is highly specific and reactive with human samples, making it ideal for use in various research applications.DBH plays a crucial role in the regulation of neurotransmitters in the brain and has been implicated in several neurological disorders, including Parkinson's disease and schizophrenia.
By targeting DBH with this monoclonal antibody, researchers can study its expression and function in different cell types and tissues, providing insights into its role in health and disease.Overall, the Dopamine Beta Hydroxylase Monoclonal Antibody is a reliable tool for researchers interested in exploring the role of DBH in neurotransmitter regulation and neurological disorders. Its specificity and reactivity make it a valuable asset for studies in neuroscience, pharmacology, and drug development.
Product Name:
Dopamine beta Hydroxylase Monoclonal Antibody
SKU:
CAB23579
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human Dopamine beta Hydroxylase (NP_000778.3).
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
Purification Method:
Affinity purification
Gene ID:
1621
Clone Number:
ARC3095
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using Dopamine beta Hydroxylase Rabbit mAb (CAB23579) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
