Dopamine beta Hydroxylase Monoclonal Antibody (CAB23579)
- SKU:
- CAB23579
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Dopamine beta Hydroxylase Monoclonal Antibody |
SKU: | CAB23579 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human Dopamine beta Hydroxylase (NP_000778.3). |
Sequence: | LVVL WTDG DTAY FADA WSDQ KGQI HLDP QQDY QLLQ VQRT PEGL TLLF KRPF GTCD PKDY LIED GTVH LVYG ILEE PFRS LEAI NGSG LQMG LQRV QLLK PNIP EPEL PSDA CTME VQAP NIQI PSQE TTYW CYIK ELPK GFSR HHII KYE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DBM; ORTHYP1; Dopamine beta Hydroxylase |
Positive Sample: | SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Single-pass type II membrane protein, chromaffin granule lumen, chromaffin granule membrane, secretory vesicle, secretory vesicle lumen, secretory vesicle membrane. |
Calculated MW: | 69kDa |
Observed MW: | 75-80kDa |
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
Purification Method: | Affinity purification |
Gene ID: | 1621 |
Clone Number: | ARC3095 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |