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DOK6 Antibody (PACO00721)

SKU:
PACO00721
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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DOK6 Antibody (PACO00721)

The Dok6 Polyclonal Antibody (PACO00721) is a valuable tool for researchers studying the Dok6 protein, a key regulator of cellular signaling pathways. This antibody is produced in rabbits and specifically targets human samples, making it ideal for a wide range of research applications.Dok6 is a member of the downstream of tyrosine kinase (Dok) family of adaptor proteins, known for their role in modulating cell growth, differentiation, and apoptosis. Dok6 specifically plays a crucial role in the regulation of neuronal development and synaptic function, making it a promising target for studies in neuroscience and neurodegenerative diseases.The Dok6 Polyclonal Antibody binds specifically to the Dok6 protein, allowing for accurate detection and quantification in various cell types and tissues.

Researchers can use this antibody in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate the function and expression of Dok6 in different biological contexts.By understanding the mechanisms by which Dok6 regulates cellular signaling, researchers can gain valuable insights into processes such as neuronal growth and synaptic plasticity. Furthermore, dysregulation of Dok6 has been implicated in various neurological disorders, making this antibody a valuable tool for research into conditions such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorders.

Antibody Name:DOK6 Antibody
Antibody SKU:PACO00721
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human Dok-6.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:DOK6; DOK5L; Docking protein 6; Downstream of tyrosine kinase 6
UniProt Protein Function:DOK6: ocking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Interacts via its PTB domain with phosphorylated Ret, promoting neurite growth. May have a role in brain development and/or maintenance. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 18q22.2

Molecular Function:insulin receptor binding; protein binding

NCBI Summary:DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
UniProt Code:Q6PKX4
NCBI GenInfo Identifier:84029601
NCBI Gene ID:220164
NCBI Accession:Q6PKX4.1
UniProt Secondary Accession:Q6PKX4,Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2, A6NNG3,
UniProt Related Accession:Q6PKX4
Molecular Weight:38,318 Da
NCBI Full Name:Docking protein 6
NCBI Synonym Full Names:docking protein 6
NCBI Official Symbol:DOK6  
NCBI Official Synonym Symbols:DOK5L; HsT3226  
NCBI Protein Information:docking protein 6
UniProt Protein Name:Docking protein 6
UniProt Synonym Protein Names:Downstream of tyrosine kinase 6
Protein Family:Docking protein
UniProt Gene Name:DOK6  
UniProt Entry Name:DOK6_HUMAN

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