DOK5 Rabbit Polyclonal Antibody (CAB13726)
- SKU:
- CAB13726
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
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Description
Product Name: | DOK5 Rabbit Polyclonal Antibody |
SKU: | CAB13726 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 237-306 of human DOK5 (NP_060901.2). |
Sequence: | LLQS VKNS MLQM KMSE RAAS LSTM VPLP RSAY WQHI TRQH STGQ LYRL QDVS SPLK LHRT ETFP AYRS EH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | IRS6; IRS-6; C20orf180; DOK5 |
Positive Sample: | Mouse kidney,Mouse liver,Rat skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol |
Calculated MW: | 35kDa |
Observed MW: | 30kDa |
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 55816 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |