The DOK5 Polyclonal Antibody (CAB13726) is a valuable tool for researchers studying DOK5, a protein involved in various cellular processes, including signal transduction and cell growth. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards DOK5 in human samples, making it an ideal choice for Western blot applications.DOK5, also known as downstream of tyrosine kinase 5, is a key player in intracellular signaling pathways that regulate cell proliferation and differentiation. Dysregulation of DOK5 has been linked to various diseases, including cancer and metabolic disorders, making it a promising target for therapeutic interventions.
Understanding the functions of DOK5 can provide insights into the underlying mechanisms of these diseases and lead to the development of targeted therapies.Overall, the DOK5 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the role of DOK5 in cellular processes and disease pathogenesis. Its specificity and reliability make it a trusted reagent for studies in cell biology, cancer research, and drug discovery.
Product Name:
DOK5 Rabbit Polyclonal Antibody
SKU:
CAB13726
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 237-306 of human DOK5 (NP_060901.2).
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55816
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DOK5 Rabbit pAb (CAB13726) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
