The DOK2 Polyclonal Antibody (CAB14084) is a valuable tool for researchers studying the protein DOK2, which plays a key role in cellular signaling pathways. The antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the DOK2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for research in cell biology, signal transduction, and cancer biology.
DOK2, also known as downstream of tyrosine kinase 2, is involved in various cellular processes such as cell proliferation, differentiation, and apoptosis. Its dysregulation has been linked to diseases like cancer, making it a potential therapeutic target. By studying the function of DOK2 using this antibody, researchers can gain valuable insights into its role in disease development and potentially identify new treatment strategies.
Product Name:
DOK2 Rabbit Polyclonal Antibody
SKU:
CAB14084
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DOK2 (NP_003965.2).
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Purification Method:
Affinity purification
Gene ID:
9046
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DOK2 antibody (CAB14084) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
