The DOCK7 Polyclonal Antibody (CAB17236) is designed for research involving DOCK7, a guanine nucleotide exchange factor that plays a crucial role in cell migration and cytoskeletal rearrangement. The antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunofluorescence.DOCK7 is known to regulate the activity of small GTPases, such as Rac1 and Cdc42, which are key players in cell migration and adhesion. Dysregulation of DOCK7 has been implicated in various diseases, including cancer and neurological disorders.
Studying the function of DOCK7 and its interactions with small GTPases can provide valuable insights into cellular processes and potential therapeutic targets.The DOCK7 Polyclonal Antibody is a valuable tool for researchers in the fields of cell biology, neuroscience, and cancer research. Its high specificity and sensitivity make it suitable for detecting and analyzing DOCK7 expression in different cell types and tissues, advancing our understanding of its role in physiological and pathological processes.
Product Name:
DOCK7 Rabbit Polyclonal Antibody
SKU:
CAB17236
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DOCK7 (NP_001354490.1).
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
85440
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DOCK7 Rabbit pAb (CAB17236) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
