DOCK2 Rabbit Polyclonal Antibody (CAB3595)
- SKU:
- CAB3595
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DOCK2 Rabbit Polyclonal Antibody |
SKU: | CAB3595 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1551-1830 of human DOCK2 (NP_004937.1). |
Sequence: | FTEE YVRD HPED QDKL THLK DLIA WQIP FLGA GIKI HEKR VSDN LRPF HDRM EECF KNLK MKVE KEYG VREM PDFD DRRV GRPR SMLR SYRQ MSII SLAS MNSD CSTP SKPT SESF DLEL ASPK TPRV EQEE PISP GSTL PEVK LRRS KKRT KRSS VVFA DEKA AAES DLKR LSRK HEFM SDTN LSEH AAIP LKAS VLSQ MSFA SQSM PTIP ALAL SVAG IPGL DEAN TSPR LSQT FLQL SDGD KKTL TRKK VNQF FKTM LASK SAEE GKQI PDSL STDL |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | IMD40; DOCK2 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endomembrane system, Peripheral membrane protein, cytoskeleton. |
Calculated MW: | 212kDa |
Observed MW: | 240kDa |
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function.
Purification Method: | Affinity purification |
Gene ID: | 1794 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |