The Dock2 Polyclonal Antibody (CAB3595) is a powerful tool for researchers studying Dock2, a protein involved in immune cell migration and immune response regulation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Dock2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.
Dock2, a guanine nucleotide exchange factor, plays a crucial role in immune cell function by regulating processes such as cell adhesion, migration, and chemotaxis. Understanding the function of Dock2 is essential for uncovering its potential role in diseases such as cancer, autoimmune disorders, and inflammatory conditions. By studying the activity of Dock2, researchers can potentially identify novel therapeutic targets for modulating immune responses in these disease settings.
Product Name:
DOCK2 Rabbit Polyclonal Antibody
SKU:
CAB3595
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1551-1830 of human DOCK2 (NP_004937.1).
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function.
Purification Method:
Affinity purification
Gene ID:
1794
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using DOCK2 Rabbit pAb (CAB3595).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
