The Dock10 Antibody (PAC038942) is a highly specific polyclonal antibody designed for research involving Dock10, a protein involved in cell migration and cytoskeletal regulation. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to Dock10, this antibody allows for the detection and analysis of Dock10 expression in various cell types, making it an ideal tool for studies in cell biology and cancer research.Dock10 is a key regulator of cell migration and adhesion, playing a crucial role in processes such as cell polarization and cytoskeletal rearrangement. Dysregulation of Dock10 expression has been implicated in various diseases, including cancer, where abnormal cell migration is a hallmark of tumor progression.
Understanding the function of Dock10 can provide valuable insights into the mechanisms underlying cancer metastasis and may lead to the development of targeted therapies aimed at inhibiting cancer cell migration.Overall, the Dock10 Antibody (PAC038942) offers researchers a reliable and sensitive tool for investigating the role of Dock10 in cellular processes and disease pathogenesis. Its high specificity and reactivity make it a valuable resource for advancing our understanding of cell migration mechanisms and identifying potential therapeutic targets for cancer treatment.
Antibody Name:
DOCK10 Antibody (PACO38942)
Antibody SKU:
PACO38942
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO38942 at dilution of 1:100.
Background:
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
Synonyms:
Dedicator of cytokinesis protein 10 (Zizimin-3), DOCK10, KIAA0694 ZIZ3
UniProt Protein Function:
DOCK10: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Belongs to the DOCK family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 2q36.2Cellular Component: membraneBiological Process: regulation of cell migration
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
