UniProt Protein Function: | DOCK10: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Belongs to the DOCK family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 2q36.2Cellular Component: membraneBiological Process: regulation of cell migration |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014] |
UniProt Code: | Q96BY6 |
NCBI GenInfo Identifier: | 15929124 |
NCBI Gene ID: | 55619 |
NCBI Accession: | BC015018 |
UniProt Secondary Accession: | Q96BY6,O75178, Q9NW06, Q9NXI8, B3FL70 |
UniProt Related Accession: | Q96BY6 |
Molecular Weight: | 249,491 Da |
NCBI Full Name: | Homo sapiens dedicator of cytokinesis 10, mRNA |
NCBI Synonym Full Names: | dedicator of cytokinesis 10 |
NCBI Official Symbol: | DOCK10Â Â |
NCBI Official Synonym Symbols: | ZIZ3; DRIP2; Nbla10300Â Â |
NCBI Protein Information: | dedicator of cytokinesis protein 10 |
UniProt Protein Name: | Dedicator of cytokinesis protein 10 |
UniProt Synonym Protein Names: | Zizimin-3 |
Protein Family: | Dedicator of cytokinesis protein |
UniProt Gene Name: | DOCK10Â Â |
UniProt Entry Name: | DOC10_HUMAN |