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DOCK1 Antibody (PACO22302)

SKU:
PACO22302
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419
Frequently bought together:

Description

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DOCK1 Antibody (PACO22302)

The DOCK1 Polyclonal Antibody (PACO22302) is specifically designed for research involving DOCK1, a guanine nucleotide exchange factor involved in cytoskeletal rearrangements and cell migration. The antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the DOCK1 protein, this antibody allows for the detection and analysis of DOCK1 in various cell types, making it a valuable tool for studies in cell biology and cancer research.DOCK1 plays a crucial role in mediating cell migration and invasion, making it a potential target for therapeutic interventions in cancer and other diseases characterized by abnormal cell motility.

By studying the activity of DOCK1, researchers can gain valuable insights into the mechanisms underlying cell movement and invasion, potentially leading to the development of novel treatment strategies. Furthermore, understanding the function of DOCK1 may provide new avenues for targeting metastasis and tumor progression in cancer therapy.

Antibody Name:DOCK1 Antibody (PACO22302)
Antibody SKU:PACO22302
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human DOCK1.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from HeLa cells, using DOCK1 antibody.
Background:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Synonyms:180 kDa protein downstream of CRK; dedicator of cytokinesis protein 1; DOC1; DOCK180;
UniProt Protein Function:DOCK1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family.Protein type: Cytoskeletal; GEFs, Rac/Rho; GEFs; Adaptor/scaffold; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 10q26.13-q26.3Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosolMolecular Function: protein binding; guanyl-nucleotide exchange factor activity; SH3 domain binding; GTPase activator activityBiological Process: integrin-mediated signaling pathway; axon guidance; cell migration; apoptosis; small GTPase mediated signal transduction; innate immune response; hemopoietic progenitor cell differentiation; phagocytosis, engulfment; blood coagulation; signal transduction; vascular endothelial growth factor receptor signaling pathway; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Code:Q14185
NCBI GenInfo Identifier:589811536
NCBI Gene ID:1793
NCBI Accession:NP_001277152.1
UniProt Secondary Accession:Q14185,A9Z1Z5
UniProt Related Accession:Q14185
Molecular Weight:
NCBI Full Name:dedicator of cytokinesis protein 1 isoform 1
NCBI Synonym Full Names:dedicator of cytokinesis 1
NCBI Official Symbol:DOCK1  
NCBI Official Synonym Symbols:ced5; DOCK180  
NCBI Protein Information:dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOwnstream of CrK
UniProt Protein Name:Dedicator of cytokinesis protein 1
UniProt Synonym Protein Names:180 kDa protein downstream of CRK; DOCK180
Protein Family:Dedicator of cytokinesis protein
UniProt Gene Name:DOCK1  
UniProt Entry Name:DOCK1_HUMAN
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