The Dock1 Polyclonal Antibody (PAC013436) is a valuable tool for researchers studying the Dock1 protein, a key player in cell signaling pathways involved in cytoskeletal reorganization and cell migration. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Dock1 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential reagent for studies in cell biology, cancer research, and immunology.
Dock1, also known as dedicator of cytokinesis 1, regulates processes such as cell adhesion, migration, and invasion, making it a crucial protein in cancer metastasis and immune cell function. Its role in promoting tumor progression and modulating immune responses underscores its importance as a therapeutic target in cancer and autoimmune diseases. By investigating the function of Dock1, researchers can uncover new insights into disease mechanisms and potentially develop novel treatments that target this protein.
DOCK1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family.Protein type: Cytoskeletal; GEFs, Rac/Rho; GEFs; Adaptor/scaffold; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 10q26.13-q26.3Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosolMolecular Function: protein binding; guanyl-nucleotide exchange factor activity; SH3 domain binding; GTPase activator activityBiological Process: integrin-mediated signaling pathway; axon guidance; cell migration; apoptosis; small GTPase mediated signal transduction; innate immune response; hemopoietic progenitor cell differentiation; phagocytosis, engulfment; blood coagulation; signal transduction; vascular endothelial growth factor receptor signaling pathway; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
