| UniProt Protein Function: | DOCK1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family.Protein type: Cytoskeletal; GEFs, Rac/Rho; GEFs; Adaptor/scaffold; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 10q26.13-q26.3Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosolMolecular Function: protein binding; guanyl-nucleotide exchange factor activity; SH3 domain binding; GTPase activator activityBiological Process: integrin-mediated signaling pathway; axon guidance; cell migration; apoptosis; small GTPase mediated signal transduction; innate immune response; hemopoietic progenitor cell differentiation; phagocytosis, engulfment; blood coagulation; signal transduction; vascular endothelial growth factor receptor signaling pathway; positive regulation of GTPase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q14185 |
| NCBI GenInfo Identifier: | 589811536 |
| NCBI Gene ID: | 1793 |
| NCBI Accession: | NP_001277152.1 |
| UniProt Secondary Accession: | Q14185,A9Z1Z5 |
| UniProt Related Accession: | Q14185 |
| Molecular Weight: | |
| NCBI Full Name: | dedicator of cytokinesis protein 1 isoform 1 |
| NCBI Synonym Full Names: | dedicator of cytokinesis 1 |
| NCBI Official Symbol: | DOCK1Â Â |
| NCBI Official Synonym Symbols: | ced5; DOCK180Â Â |
| NCBI Protein Information: | dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOwnstream of CrK |
| UniProt Protein Name: | Dedicator of cytokinesis protein 1 |
| UniProt Synonym Protein Names: | 180 kDa protein downstream of CRK; DOCK180 |
| Protein Family: | Dedicator of cytokinesis protein |
| UniProt Gene Name: | DOCK1Â Â |
| UniProt Entry Name: | DOCK1_HUMAN |
