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DOCK1 Antibody (PACO03576)

SKU:
PACO03576
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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DOCK1 Antibody (PACO03576)

The Dock1 Monoclonal Antibody (PACO03576) is a valuable tool for researchers studying the Dock1 protein, a key player in regulating cell migration and cytoskeletal reorganization. This antibody, produced with high specificity in rabbits, is optimized for detection of Dock1 in human samples and is validated for use in Western blot applications.Dock1, also known as dedicator of cytokinesis 1, is essential for processes such as cell adhesion, migration, and invasion, making it a pivotal molecule in cancer metastasis and immune cell function.

By targeting Dock1 with this antibody, researchers can gain valuable insights into its role in various cellular pathways and its potential as a therapeutic target for diseases such as cancer and inflammatory disorders.With its high reactivity and specificity, the Dock1 Monoclonal Antibody is a reliable tool for investigating the function and regulation of Dock1 in diverse cellular contexts, making it a valuable asset for studies in cancer biology, immunology, and cell biology.

Antibody Name:DOCK1 Antibody
Antibody SKU:PACO03576
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the C-terminal region of human DOCK 180.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:DOCK1; Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180
UniProt Protein Function:DOCK1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family.Protein type: Cytoskeletal; GEFs, Rac/Rho; GEFs; Adaptor/scaffold; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 10q26.13-q26.3Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosolMolecular Function: protein binding; guanyl-nucleotide exchange factor activity; SH3 domain binding; GTPase activator activityBiological Process: integrin-mediated signaling pathway; axon guidance; cell migration; apoptosis; small GTPase mediated signal transduction; innate immune response; hemopoietic progenitor cell differentiation; phagocytosis, engulfment; blood coagulation; signal transduction; vascular endothelial growth factor receptor signaling pathway; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Code:Q14185
NCBI GenInfo Identifier:589811536
NCBI Gene ID:1793
NCBI Accession:NP_001277152.1
UniProt Secondary Accession:Q14185,A9Z1Z5
UniProt Related Accession:Q14185
Molecular Weight:
NCBI Full Name:dedicator of cytokinesis protein 1 isoform 1
NCBI Synonym Full Names:dedicator of cytokinesis 1
NCBI Official Symbol:DOCK1  
NCBI Official Synonym Symbols:ced5; DOCK180  
NCBI Protein Information:dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOwnstream of CrK
UniProt Protein Name:Dedicator of cytokinesis protein 1
UniProt Synonym Protein Names:180 kDa protein downstream of CRK; DOCK180
Protein Family:Dedicator of cytokinesis protein
UniProt Gene Name:DOCK1  
UniProt Entry Name:DOCK1_HUMAN

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