The DNMT3L Polyclonal Antibody (CAB2342) is a vital tool for research involving DNMT3L, a protein involved in epigenetic regulation and gene expression. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the DNMT3L protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent choice for studies in epigenetics, developmental biology, and reproduction research.DNMT3L is an essential factor in establishing DNA methylation patterns during embryonic development and maintaining genomic imprinting. Dysregulation of DNMT3L has been linked to various diseases, including cancer and developmental disorders.
By gaining a deeper understanding of DNMT3L's function, researchers can uncover new insights into epigenetic mechanisms and potentially identify novel therapeutic targets for diseases influenced by DNA methylation patterns.Overall, the DNMT3L Polyclonal Antibody offers researchers a reliable tool for investigating the role of DNMT3L in gene regulation, development, and disease pathology. Its high specificity and sensitivity make it an invaluable asset in advancing scientific knowledge and discovering new possibilities in the field of epigenetics.
Product Name:
DNMT3L Rabbit Polyclonal Antibody
SKU:
CAB2342
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DNMT3L (NP_787063.1).
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
29947
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat testis using DNMT3L Rabbit pAb (CAB2342) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
