DNMT3B Rabbit Polyclonal Antibody (CAB2899)
- SKU:
- CAB2899
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DNMT3B Rabbit Polyclonal Antibody |
SKU: | CAB2899 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-475 of human DNMT3B (NP_008823.1). |
Sequence: | IEGL KPNN TQPV VNKS KVRR AGSR KLES RKYE NKTR RRTA DDSA TSDY CPAP KRLK TNCY NNGK DRGD EDQS REQM ASDV ANNK SSLE DGCL SCGR KNPV SFHP LFEG GLCQ TCRD RFLE LFYM YDDD GYQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | ICF; ICF1; FSHD4; M.HsaIIIB; DNMT3B |
Positive Sample: | U-251MG,HCT116,mouse testis,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 96kDa |
Observed MW: | 110kDa |
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Purification Method: | Affinity purification |
Gene ID: | 1789 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |