DNMT3B Rabbit Polyclonal Antibody (CAB11079)
- SKU:
- CAB11079
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DNMT3B Rabbit Polyclonal Antibody |
SKU: | CAB11079 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 1-200 of human DNMT3B (NP_008823.1). |
Sequence: | MKGD TRHL NGEE DAGG REDS ILVN GACS DQSS DSPP ILEA IRTP EIRG RRSS SRLS KREV SSLL SYTQ DLTG DGDG EDGD GSDT PVMP KLFR ETRT RSES PAVR TRNN NSVS SRER HRPS PRST RGRQ GRNH VDES PVEF PATR SLRR RATA SAGT PWPS PPSS YLTI DLTD DTED THGT PQSS STPY ARLA QDSQ QGGM |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | ICF; ICF1; FSHD4; M.HsaIIIB; DNMT3B |
Positive Sample: | C6,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 96kDa |
Observed MW: | 96kDa/110kDa |
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Purification Method: | Affinity purification |
Gene ID: | 1789 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |