The DNM1L Polyclonal Antibody is a valuable tool for researchers studying DNM1L, a protein involved in mitochondrial fission and apoptosis. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the DNM1L protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for research in the fields of cell biology and neuroscience.DNM1L, also known as dynamin-related protein 1, plays a crucial role in the regulation of mitochondrial dynamics and cell death. Dysregulation of DNM1L has been implicated in various diseases, including neurodegenerative disorders and cancer.
By studying the function of DNM1L, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially identify novel therapeutic targets.Overall, the DNM1L Polyclonal Antibody is a valuable asset for researchers looking to explore the role of DNM1L in mitochondrial dynamics, apoptosis, and disease pathogenesis. Its high specificity and sensitivity make it a reliable tool for advancing our understanding of cellular processes and developing innovative treatments for a range of human illnesses.
Product Name:
DNM1L Polyclonal Antibody
SKU:
CAB21311
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 437-736 of human DNM1L (NP_036192.2).
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using DRP1 Rabbit pAb (CAB21311) at dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.
