The DNM1L Polyclonal Antibody (CAB2586) is a valuable tool for researchers studying DNM1L, a key protein involved in mitochondrial dynamics and fission processes. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the DNM1L protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in the fields of cell biology, neurology, and metabolism.DNM1L, also known as dynamin-1-like protein, plays a crucial role in maintaining mitochondrial health and function by regulating organelle division and clearance.
Dysregulation of DNM1L has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. Therefore, understanding the function and regulation of DNM1L is essential for developing targeted therapies for these conditions.By utilizing the DNM1L Polyclonal Antibody (CAB2586), researchers can gain valuable insights into the mechanisms underlying mitochondrial dynamics and fission processes, ultimately advancing our understanding of cellular homeostasis and disease pathology.
Product Name:
DRP1 Rabbit Polyclonal Antibody
SKU:
CAB2586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 411-710 of human DRP1 (NP_036193.2).
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DRP1 Rabbit pAb (CAB2586) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
