The DNM1L Polyclonal Antibody (CAB17069) is a valuable tool for researchers studying the role of DNM1L, also known as dynamin-1-like protein, in mitochondrial dynamics and cell division. This antibody, produced in rabbits, offers high reactivity with human samples and is validated for use in Western blot applications. By targeting the DNM1L protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in cell biology and neurodegenerative diseases.DNM1L is a key regulator of mitochondrial fission, playing a crucial role in maintaining mitochondrial function and cellular homeostasis.
Dysregulation of DNM1L has been linked to various diseases, including neurodegenerative disorders like Parkinson's and Alzheimer's. Understanding the function of DNM1L can provide insights into disease mechanisms and potential therapeutic targets for intervention.By utilizing the DNM1L Polyclonal Antibody (CAB17069), researchers can further explore the complex role of DNM1L in cellular processes and disease pathology, advancing our understanding of mitochondrial dynamics and potential treatment strategies for related disorders.
Product Name:
[KO Validated] DRP1 Rabbit Polyclonal Antibody
SKU:
CAB17069
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 437-736 of human DNM1L (NP_036192.2).
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using DRP1 Rabbit pAb (CAB17069) at dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.
