The DNM1L Polyclonal Antibody (CAB16661) is a valuable tool for researchers studying DNM1L, a protein involved in mitochondrial dynamics and fission. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to DNM1L, this antibody allows for the detection and analysis of this protein in various cell types, making it ideal for investigations in mitochondrial biology and diseases related to dysfunction in mitochondrial dynamics.DNM1L, also known as dynamin-1-like protein, plays a crucial role in mitochondrial fission, a process essential for maintaining mitochondrial function and cellular homeostasis.
Dysregulation of DNM1L has been associated with various diseases, including neurodegenerative disorders and cancer. By studying the role of DNM1L, researchers can gain insight into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.Overall, the DNM1L Polyclonal Antibody is a valuable tool for researchers interested in studying mitochondrial dynamics and their implications in disease pathogenesis. Its specificity and sensitivity make it an excellent choice for Western blotting experiments aimed at elucidating the role of DNM1L in health and disease.
Product Name:
DRP1 Rabbit Polyclonal Antibody
SKU:
CAB16661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 437-736 of human DNM1L (NP_036192.2).
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DRP1 antibody (CAB16661) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
