The DNAse2 Polyclonal Antibody (PACO08900) is a valuable tool for researchers studying DNAse2, an essential enzyme involved in the breakdown of DNA within the body. This antibody, derived from rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to DNAse2, this antibody allows for precise detection and analysis of the enzyme in various cell types, making it an ideal choice for studies in molecular biology and genetics.DNAse2 is a key player in the process of DNA degradation, which is crucial for the maintenance of cellular function and proper immune responses.
Dysregulation of DNAse2 activity has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. By investigating the role of DNAse2 in these pathological processes, researchers can gain valuable insights that may lead to the development of novel therapeutic interventions targeting DNAse2 and its associated pathways.
deoxyribonuclease II, lysosomal;DNASE2;DNASE2A;DNL;DNL2 ;
UniProt Protein Function:
DNASE2: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. Belongs to the DNase II family.Protein type: EC 3.1.22.1; DeoxyribonucleaseChromosomal Location of Human Ortholog: 19p13.2Cellular Component: lysosome; intracellularMolecular Function: DNA binding; deoxyribonuclease II activityBiological Process: erythrocyte differentiation; DNA fragmentation during apoptosis; DNA metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
