DNAJC3 Antibody (PACO46506)
- SKU:
- PACO46506
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DNAJC3 Antibody (PACO46506)
The DNAJC3 Polyclonal Antibody (PAC046506) is a valuable tool for researchers studying DNAJC3, a protein involved in protein folding and quality control within the cell. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is suitable for use in Western blot applications. By binding to the DNAJC3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and protein folding research.
DNAJC3, also known as the DnaJ homolog subfamily C member 3, is a crucial player in the cellular response to protein misfolding and stress. Its role in maintaining protein homeostasis makes it an intriguing target for studying neurodegenerative diseases, such as Alzheimer's and Parkinson's, as well as other protein misfolding disorders. Understanding the function of DNAJC3 is essential for developing therapeutic strategies aimed at restoring protein balance and preventing disease progression.
| Antibody Name: | DNAJC3 Antibody (PACO46506) |
| Antibody SKU: | PACO46506 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO46506 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO46506 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO46506 at dilution of 1:100. |
| Background: | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-α at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid, starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| Synonyms: | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58), DNAJC3, P58IPK PRKRI |
| UniProt Protein Function: | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q13217 |
| NCBI GenInfo Identifier: | 5453980 |
| NCBI Gene ID: | 5611 |
| NCBI Accession: | NP_006251.1 |
| UniProt Secondary Accession: | Q13217,Q86WT9, Q8N4N2 |
| UniProt Related Accession: | Q13217 |
| Molecular Weight: | 55 |
| NCBI Full Name: | dnaJ homolog subfamily C member 3 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C3 |
| NCBI Official Symbol: | DNAJC3Â Â |
| NCBI Official Synonym Symbols: | P58; HP58; ACPHD; ERdj6; PRKRI; P58IPKÂ Â |
| NCBI Protein Information: | dnaJ homolog subfamily C member 3 |
| UniProt Protein Name: | DnaJ homolog subfamily C member 3 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58 |
| Protein Family: | |
| UniProt Gene Name: | DNAJC3Â Â |
| UniProt Entry Name: |
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