The DNAJC24 Polyclonal Antibody (CAB15560) is a valuable tool for researchers studying DNAJC24, a member of the heat shock protein family involved in protein folding and quality control within the cell. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.DNAJC24 plays a crucial role in cellular processes such as protein folding and degradation, making it a key target for studies in molecular biology and cell physiology. By binding specifically to the DNAJC24 protein, this antibody enables researchers to detect and analyze its expression levels in various cell types, providing valuable insights into its function and potential implications in disease.
The significance of DNAJC24 in cellular homeostasis and protein quality control makes it a promising candidate for research into neurodegenerative diseases, cancer, and other conditions characterized by protein misfolding and aggregation. Understanding the role of DNAJC24 in these disease contexts is essential for the development of targeted therapies and interventions aimed at restoring protein homeostasis and preventing disease progression.
Product Name:
DNAJC24 Rabbit Polyclonal Antibody
SKU:
CAB15560
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-149 of human DNAJC24 (NP_859057.4).
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).
Purification Method:
Affinity purification
Gene ID:
120526
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNAJC24 Rabbit pAb (CAB15560) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
