The DNAJC19 Polyclonal Antibody (CAB5146) is a valuable tool for researchers studying DNAJC19, a protein involved in mitochondrial function and cellular metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to DNAJC19, researchers can detect and analyze the protein in various cell types, making it an ideal reagent for studies in biochemistry, cell biology, and mitochondrial disorders.DNAJC19 is a co-chaperone protein that plays a crucial role in protein folding and assembly within the mitochondria. Dysfunction of DNAJC19 has been associated with various mitochondrial disorders, including dilated cardiomyopathy and sensorineural deafness.
By understanding the function and regulation of DNAJC19, researchers can gain insights into the pathogenesis of these disorders and potentially identify therapeutic targets for intervention.Overall, the DNAJC19 Polyclonal Antibody (CAB5146) provides researchers with a reliable tool for investigating the role of DNAJC19 in mitochondrial biology and disease pathology. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of cellular metabolism and the development of targeted therapies for mitochondrial disorders.
Product Name:
DNAJC19 Rabbit Polyclonal Antibody
SKU:
CAB5146
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human DNAJC19 (NP_660304.1).
The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19.
Purification Method:
Affinity purification
Gene ID:
131118
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DNAJC19 Rabbit pAb (CAB5146) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
