The DNAJC19 Polyclonal Antibody (CAB14961) is a valuable tool for researchers studying DNAJC19, a mitochondria-localized DnaJ chaperone involved in protein translocation. This antibody is raised in rabbits and has been validated for use in various applications, including Western blot analysis. DNAJC19 is known for its role in protein folding and assembly in the mitochondria, which is crucial for cellular function and energy production. Dysregulation of DNAJC19 has been linked to mitochondrial disorders and neurodegenerative diseases, making it a target of interest for research in these fields.With its high reactivity towards DNAJC19 in human samples, this polyclonal antibody enables the detection and analysis of DNAJC19 protein expression in various cell types.
Its use is ideal for studies in mitochondrial biology, protein folding mechanisms, and disease pathogenesis related to DNAJC19 dysfunction.By understanding the function and regulation of DNAJC19, researchers can gain insights into mitochondrial biology and develop potential therapies for mitochondrial diseases and neurodegenerative disorders. The DNAJC19 Polyclonal Antibody is a valuable tool for advancing research in these areas.
Product Name:
DNAJC19 Rabbit Polyclonal Antibody
SKU:
CAB14961
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human DNAJC19 (NP_660304.1).
The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19.
Purification Method:
Affinity purification
Gene ID:
131118
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of T-47D, using DNAJC19 Rabbit pAb (CAB14961) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
