The DNAJC10 Polyclonal Antibody (CAB12143) is a valuable tool for researchers studying DNAJC10, a protein involved in chaperone-mediated protein folding and intracellular trafficking. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to DNAJC10, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and protein quality control mechanisms.
DNAJC10, also known as ERdj5, is a key player in endoplasmic reticulum (ER) quality control processes, ensuring proper folding of proteins and preventing ER stress-induced cell death. Its crucial role in protein homeostasis positions it as a promising target for research on neurodegenerative diseases, cancer, and metabolic disorders. By unraveling the mechanisms through which DNAJC10 functions, researchers can gain valuable insights into disease pathogenesis and potentially identify novel therapeutic strategies.
Product Name:
DNAJC10 Rabbit Polyclonal Antibody
SKU:
CAB12143
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 614-793 of human DNAJC10 (NP_061854.1).
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
54431
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNAJC10 Rabbit pAb (CAB12143) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
