The DNAJB8 Polyclonal Antibody (PAC038590) is a valuable tool for researchers studying DNAJB8, a member of the heat shock protein family that plays a role in protein folding and stress response pathways. This antibody is produced in rabbits and is highly specific for human samples, making it ideal for use in Western blot applications. By binding to the DNAJB8 protein, this antibody allows for the detection and analysis of DNAJB8 in various cell types, making it a valuable tool for studies in molecular and cellular biology.DNAJB8, also known as DNAJ homolog subfamily B member 8, is involved in facilitating the correct folding of proteins and preventing their aggregation under conditions of cellular stress.
Its function in protein quality control mechanisms makes it a potential target for research into various diseases, including neurodegenerative disorders and cancer. Understanding the role of DNAJB8 in cellular processes is essential for the development of therapies that target protein misfolding and aggregation, offering potential insights into disease mechanisms and treatment strategies.
Western blot. All lanes: DNAJB8 antibody at 8µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Mouse brain tissue. Lane 3: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 26 kDa. Observed band size: 26 kDa.
Immunohistochemistry of paraffin-embedded human colon tissue using PACO38590 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO38590 at dilution of 1:100.
Background:
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
Synonyms:
DnaJ homolog subfamily B member 8, DNAJB8
UniProt Protein Function:
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
