The DNAJB8 Polyclonal Antibody (PACO08883) is a valuable tool for researchers studying the DNAJB8 protein, an essential component in protein folding and cellular stress response. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.DNAJB8, a member of the DNAJ/HSP40 co-chaperone family, plays a crucial role in assisting protein folding and preventing protein aggregation under stressful conditions. Its involvement in cellular homeostasis and stress response makes it a promising target for studying various diseases, including neurodegenerative disorders and cancer.
By targeting the DNAJB8 protein, researchers can gain insights into its function and significance in maintaining cellular integrity and responding to stress. This antibody enables the detection and analysis of DNAJB8 in various cell types, making it a valuable tool for studies in cell biology, protein degradation pathways, and disease mechanisms. Understanding the role of DNAJB8 can lead to new therapeutic strategies for diseases characterized by protein misfolding and cellular stress.
DnaJ (Hsp40) homolog, subfamily B, member 8;DNAJB8;DJ6;MGC33884 ;
UniProt Protein Function:
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
