The DNAJB6 Polyclonal Antibody (CAB7052) is a valuable tool for research involving DNAJB6, a member of the heat shock protein (HSP40) family known for its role in protein folding and quality control. This antibody, produced in rabbits, is highly specific to human samples and has been rigorously validated for use in Western blot applications. By targeting the DNAJB6 protein, researchers can effectively study its function and expression levels in various cell types, making it a versatile tool for investigations in molecular biology and protein research.
DNAJB6 is involved in chaperone-mediated protein folding and stability, making it a key player in maintaining cellular proteostasis. Dysregulation of DNAJB6 has been linked to neurodegenerative diseases, cancer, and other protein misfolding disorders, highlighting its importance in cellular health. By using the DNAJB6 Polyclonal Antibody, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
DNAJB6 Rabbit Polyclonal Antibody
SKU:
CAB7052
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 177-326 of human DNAJB6 (NP_490647.1).
Cytoplasm, Nucleus, Z line, myofibril, perinuclear region, sarcomere.
Calculated MW:
36kDa
Observed MW:
38kDa
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.
Purification Method:
Affinity purification
Gene ID:
10049
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNAJB6 Rabbit pAb (CAB7052) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
