DNAJB5 Antibody (PACO26269)
- SKU:
- PACO26269
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
DNAJB5 Antibody (PACO26269)
The DNAJB5 Polyclonal Antibody (PAC026269) is a valuable tool for researchers studying the DNAJB5 protein, a member of the HSP40/DNAJ family involved in protein folding and quality control. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to DNAJB5, researchers can detect and analyze this crucial molecular chaperone in a variety of cell types.DNAJB5 plays a key role in maintaining protein homeostasis and preventing aggregation of misfolded proteins, making it a promising target for studies related to protein folding disorders, neurodegenerative diseases, and cancer.
Understanding the function of DNAJB5 is essential for uncovering its therapeutic potential in these areas, as well as for elucidating its mechanisms of action in cellular stress response pathways.Overall, the DNAJB5 Polyclonal Antibody is a reliable tool for investigating the biological functions of DNAJB5 and advancing research in protein folding and quality control mechanisms. Its versatility and specificity make it a valuable asset for scientists working in the fields of molecular biology, biochemistry, and cell biology.
| Antibody Name: | DNAJB5 Antibody (PACO26269) |
| Antibody SKU: | PACO26269 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DnaJ homolog subfamily B member 5 protein (1-344AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: HepG2 whole cell lysate All lanes: DNAJB5 antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 40, 48, 52 kDa Observed band size: 48 kDa . |
 | Immunohistochemistry analysis of human glioma using PACO26269 at dilution of 1:100. |
| Synonyms: | DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40), DNAJB5, HSC40 |
| UniProt Protein Function: | DNAJB5: Expressed under normal conditions, its expression can further be increased after various stress treatments. 2 isoforms of the human protein are produced by alternative splicing.Protein type: ChaperoneChromosomal Location of Human Ortholog: 9p13.3Cellular Component: nucleus; cytosolMolecular Function: protein binding; chaperone binding; unfolded protein bindingBiological Process: protein folding; negative regulation of transcription from RNA polymerase II promoter; response to unfolded protein |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017] |
| UniProt Code: | O75953 |
| NCBI GenInfo Identifier: | 18202150 |
| NCBI Gene ID: | 25822 |
| NCBI Accession: | O75953.1 |
| UniProt Secondary Accession: | O75953 |
| UniProt Related Accession: | O75953 |
| Molecular Weight: | |
| NCBI Full Name: | DnaJ homolog subfamily B member 5 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member B5 |
| NCBI Official Symbol: | DNAJB5Â Â |
| NCBI Official Synonym Symbols: | Hsc40Â Â |
| NCBI Protein Information: | dnaJ homolog subfamily B member 5 |
| UniProt Protein Name: | DnaJ homolog subfamily B member 5 |
| UniProt Synonym Protein Names: | Heat shock protein Hsp40-2; Heat shock protein Hsp40-3; Heat shock protein cognate 40; Hsc40 |
| Protein Family: | |
| UniProt Gene Name: | DNAJB5Â Â |
| UniProt Entry Name: | DNJB5_HUMAN |
| Antibodies |
| DNAJB5 Antibody (PACO08881) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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