The DNAJB5 Polyclonal Antibody (PACO08881) is a valuable tool for research involving DNAJB5, a member of the DnaJ/Hsp40 protein family known for its role in protein folding and quality control. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications. By binding to DNAJB5, the antibody allows for the detection and analysis of this protein in a variety of cell types, making it a versatile option for studies in cell biology and protein quality control mechanisms.
DNAJB5 is a chaperone protein that assists in proper protein folding, preventing misfolding and aggregation that can lead to cellular stress and dysfunction. Dysregulation of DNAJB5 has been implicated in various neurodegenerative diseases, making it an important target for research into protein misfolding disorders. Studying the function and regulation of DNAJB5 is crucial for understanding the underlying mechanisms of these diseases, potentially leading to the development of therapeutic interventions targeting protein folding pathways.
DnaJ (Hsp40) homolog, subfamily B, member 5;DNAJB5;Hsc40;KIAA1045 ;
UniProt Protein Function:
DNAJB5: Expressed under normal conditions, its expression can further be increased after various stress treatments. 2 isoforms of the human protein are produced by alternative splicing.Protein type: ChaperoneChromosomal Location of Human Ortholog: 9p13.3Cellular Component: nucleus; cytosolMolecular Function: protein binding; chaperone binding; unfolded protein bindingBiological Process: protein folding; negative regulation of transcription from RNA polymerase II promoter; response to unfolded protein
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]
