The DNAJB12 Polyclonal Antibody (CAB14625) is a valuable tool for researchers studying DNAJB12, a member of the heat shock protein family known for its chaperone activity in protein folding and quality control. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to DNAJB12, allowing for detection and analysis in a variety of cell types, making it ideal for research in cell biology and protein regulation.DNAJB12, also known as heat shock protein 40 (Hsp40), plays a crucial role in maintaining protein homeostasis and protecting against cellular stress.
Its function as a chaperone protein ensures proper folding and stability of client proteins, making it a key player in cellular function and response to environmental stressors. Research on DNAJB12 is essential for understanding its role in diseases such as neurodegenerative disorders, cancer, and protein misfolding diseases, with potential implications for therapeutic development in these areas.Overall, the DNAJB12 Polyclonal Antibody (CAB14625) offers researchers a reliable tool for studying the function and regulation of DNAJB12, providing valuable insights into protein quality control mechanisms and their role in cellular health and disease.
Product Name:
DNAJB12 Rabbit Polyclonal Antibody
SKU:
CAB14625
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-409 of human DNAJB12 (NP_060096.3).
DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).
Purification Method:
Affinity purification
Gene ID:
54788
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNAJB12 Rabbit pAb (CAB14625) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
