The DNAI1 Polyclonal Antibody (CAB12130) is a valuable tool for researchers studying DNAI1, a key protein involved in the function of cilia in cells. Cilia are hair-like structures on the surface of cells that play a critical role in cell motility and signaling pathways. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.By binding specifically to the DNAI1 protein, this antibody enables the detection and analysis of DNAI1 in various cell types, making it ideal for studies in cell biology and genetics.
Understanding the function of DNAI1 is important for research into conditions like primary ciliary dyskinesia, a genetic disorder that affects cilia function and can lead to respiratory and fertility issues.Overall, the DNAI1 Polyclonal Antibody is a valuable tool for researchers looking to explore the role of DNAI1 in cilia function and its potential implications for human health.
Product Name:
DNAI1 Rabbit Polyclonal Antibody
SKU:
CAB12130
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-699 of human DNAI1 (NP_036276.1).
This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
27019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNAI1 Rabbit pAb (CAB12130) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
