The DNAH7 Polyclonal Antibody (PAC046898) is a valuable tool for research involving DNAH7, a protein essential for the function of cilia and flagella. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the DNAH7 protein, this antibody allows for the detection and analysis of DNAH7 in various cell types, making it ideal for studies in cell biology and genetic disorders related to ciliary dysfunction.DNAH7 is a dynein axonemal heavy chain protein that plays a crucial role in the motility of cilia and flagella.
Dysfunction of DNAH7 has been associated with a variety of genetic disorders, including primary ciliary dyskinesia and infertility. Understanding the function of DNAH7 is essential for unraveling the mechanisms underlying these conditions and developing targeted therapeutic interventions. Researchers studying ciliary biology and genetic diseases will benefit from the high specificity and reliability of the DNAH7 Polyclonal Antibody in their experiments.
Antibody Name:
DNAH7 Antibody (PACO46898)
Antibody SKU:
PACO46898
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Dynein heavy chain 7, axonemal protein (730-903AA)
Immunofluorescent analysis of HepG2 cells using PACO46898 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
Synonyms:
Dynein heavy chain 7, axonemal (Axonemal β dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2), DNAH7, KIAA0944
UniProt Protein Function:
DNAH7: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Belongs to the dynein heavy chain family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Microtubule-binding; MotorChromosomal Location of Human Ortholog: 2q32.3Cellular Component: microtubule; axonemal dynein complex; ciliumMolecular Function: ATPase activity; microtubule motor activity; calcium ion binding; ATP bindingBiological Process: metabolic process; ciliary or flagellar motility
UniProt Protein Details:
NCBI Summary:
DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]
dynein heavy chain 7, axonemal; hDHC2; ciliary dynein heavy chain 7; axonemal dynein heavy chain 7; dynein heavy chain-like protein 2; axonemal beta dynein heavy chain 7; dynein, axonemal, heavy polypeptide 7
UniProt Protein Name:
Dynein heavy chain 7, axonemal
UniProt Synonym Protein Names:
Axonemal beta dynein heavy chain 7; Ciliary dynein heavy chain 7; Dynein heavy chain-like protein 2; hDHC2
