The DNAH5 Polyclonal Antibody (CAB17472) is a valuable tool for researchers studying the DNAH5 protein, which is essential for the function of cilia and flagella. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DNAH5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and genetics.DNAH5 is a key component of the dynein complex, which plays a crucial role in the movement of cilia and flagella.
Defects in DNAH5 can lead to ciliary dysfunction, resulting in conditions such as primary ciliary dyskinesia. Research into the function and regulation of DNAH5 is important for understanding the mechanisms underlying cilia-related diseases and for developing potential therapeutic interventions. By using the DNAH5 Polyclonal Antibody, researchers can further explore the role of DNAH5 in various cellular processes and gain insights into its implications for human health.
Product Name:
DNAH5 Polyclonal Antibody
SKU:
CAB17472
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human DNAH5 (NP_001360.1).
9+0 motile cilium, 9+2 motile cilium, axoneme, cytoplasm, extracellular region
Calculated MW:
529kDa
Observed MW:
529kDa
This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects.
Purification Method:
Affinity purification
Gene ID:
1767
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse testis, using DNAH5 Rabbit pAb (CAB17472) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
