The DNAH1 Antibody (PAC047122) is a valuable tool for researchers studying DNAH1, a protein involved in the movement of cilia and flagella. This polyclonal antibody, produced in rabbits, has been validated for use in various applications, including Western blotting. By binding specifically to DNAH1, this antibody allows for the detection and analysis of the protein in different cell types.DNAH1 is essential for the proper function of cilia and flagella, which play important roles in cell motility and signaling. Mutations in DNAH1 have been associated with ciliopathies, a group of genetic disorders affecting cilia structure and function.
Research on DNAH1 is critical for understanding the mechanisms underlying these disorders and developing potential therapeutics.With its high reactivity and specificity, the DNAH1 Antibody is a valuable tool for studies in cell biology, developmental biology, and genetics. Its ability to detect DNAH1 protein levels in various samples makes it an essential component for researchers investigating cilia-related diseases and cellular motility.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO47122 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO47122 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO47122 at dilution of 1:100.
Background:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Synonyms:
Dynein heavy chain 1, axonemal (Axonemal β dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7), DNAH1, DHC7 DNAHC1 KIAA1410
UniProt Protein Function:
DNAH1: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 3p21.1Biological Process: sperm motility
