DNA polymerase eta Rabbit Polyclonal Antibody (CAB1833)
- SKU:
- CAB1833
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | DNA polymerase eta Rabbit Polyclonal Antibody |
SKU: | CAB1833 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 322-520 of human DNA polymerase eta (NP_006493.1). |
Sequence: | SKNF PGKT ALAT REQV QWWL LQLA QELE ERLT KDRN DNDR VATQ LVVS IRVQ GDKR LSSL RRCC ALTR YDAH KMSH DAFT VIKN CNTS GIQT EWSP PLTM LFLC ATKF SASA PSSS TDIT SFLS SDPS SLPK VPVT SSEA KTQG SGPA VTAT KKAT TSLE SFFQ KAAE RQKV KEAS LSSL TAPT QAPM SNSP SKPS LPF |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | XPV; XP-V; RAD30; RAD30A; DNA polymerase eta |
Positive Sample: | Jurkat,HepG2,Mouse thymus,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 78kDa |
Observed MW: | 80kDa |
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5429 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |