The DMXL2 polyclonal antibody (PAC046806) is a useful tool for researchers studying DMXL2, a protein involved in neuronal development and function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the DMXL2 protein, this antibody allows for the detection and analysis of DMXL2 in a variety of cell types, making it an excellent choice for studies in neuroscience and neurobiology.
DMXL2 is known to be important for regulating neuronal activity and synaptic transmission, making it a key player in the nervous system. Research on DMXL2 can provide insights into neurological disorders and conditions affecting brain function. This antibody is a valuable resource for scientists looking to better understand the role of DMXL2 in the nervous system and its potential implications for disease treatment and prevention.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46806 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46806 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).
Synonyms:
DmX-like protein 2 (Rabconnectin-3), DMXL2, KIAA0856
UniProt Protein Function:
RC3: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Vesicle; Membrane protein, peripheralChromosomal Location of Human Ortholog: 15q21.2Cellular Component: extracellular space; synaptic vesicle; synaptic vesicle membrane; cell junctionMolecular Function: Rab GTPase bindingDisease: Polyendocrine-polyneuropathy Syndrome
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
