DMTN Antibody (PACO00698)
- SKU:
- PACO00698
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
DMTN Antibody (PACO00698)
The DMTN Polyclonal Antibody (PACO00698) is a valuable tool for researchers studying DMTN, a protein involved in cellular transport and organization. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the DMTN protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in cell biology and disease research.DMTN, also known as dystrobrevin beta, is essential for maintaining cellular structure and function, particularly in processes involving membrane trafficking and cytoskeletal organization.
Its role in these fundamental cellular functions makes it a promising target for research in areas such as cancer, genetic disorders, and neurodegenerative diseases. Understanding the function of DMTN is crucial for unraveling its implications in health and disease, ultimately paving the way for new therapeutic strategies.
| Antibody Name: | DMTN Antibody |
| Antibody SKU: | PACO00698 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from human Dematin around the non-phosphorylation site of S403. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | EPB49; DMT; Dematin; Erythrocyte membrane protein band 4.9 |
| UniProt Protein Function: | dematin: a probable DNA binding protein, with a Myb-like DNA-binding and ELM2 domain. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Tumor suppressor; Actin-binding Chromosomal Location of Human Ortholog: 8p21.1 Cellular Component: actin cytoskeleton; actin filament; cell projection membrane; cortical cytoskeleton; cytoplasmic membrane-bound vesicle; cytosol; endomembrane system; perinuclear region of cytoplasm; plasma membrane Molecular Function:actin binding; protein binding; protein self-association; receptor binding; spectrin binding Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; actin filament capping; cytoskeleton organization and biogenesis; erythrocyte development; negative regulation of focal adhesion formation; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of blood coagulation; protein complex assembly; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of filopodium formation; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q08495 |
| NCBI GenInfo Identifier: | 22654240 |
| NCBI Gene ID: | 2039 |
| NCBI Accession: | Q08495.3 |
| UniProt Secondary Accession: | Q08495,Q13215, Q9BRE3, A8K0T5, B3KP70, B3KRH3, B4DI75 E9PEJ0, |
| UniProt Related Accession: | Q08495 |
| Molecular Weight: | 41,558 Da |
| NCBI Full Name: | Dematin |
| NCBI Synonym Full Names: | dematin actin binding protein |
| NCBI Official Symbol: | DMTNÂ Â |
| NCBI Official Synonym Symbols: | DMT; EPB49Â Â |
| NCBI Protein Information: | dematin |
| UniProt Protein Name: | Dematin |
| UniProt Synonym Protein Names: | Dematin actin-binding protein; Erythrocyte membrane protein band 4.9 |
| Protein Family: | Dematin |
| UniProt Gene Name: | DMTNÂ Â |
| UniProt Entry Name: | DEMA_HUMAN |
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