The DMTF1 Polyclonal Antibody (CAB17067) is specifically designed for research involving DMTF1, a transcription factor known for its role in the regulation of cell growth and differentiation. This antibody, raised in rabbits, is highly sensitive and specific for use in various research applications, including Western blotting and immunohistochemistry.DMTF1, also known as cyclin D binding Myb-like transcription factor 1, plays a crucial role in the control of cell cycle progression and cell fate determination. Its functions have been linked to various physiological processes, including embryonic development, tissue regeneration, and oncogenesis. By targeting DMTF1, researchers can gain insights into the molecular mechanisms underlying these processes and potentially discover novel therapeutic targets for cancer and other diseases.
With its high reactivity towards human samples and proven reliability in experimental settings, the DMTF1 Polyclonal Antibody is an indispensable tool for investigating the functions and regulatory networks of DMTF1 in both normal and pathological conditions. Its versatility and specificity make it an ideal choice for scientists working in the fields of molecular biology, cancer research, and developmental biology. Unlock the mysteries of DMTF1 and advance your research with this powerful antibody.
Product Name:
DMTF1 Rabbit Polyclonal Antibody
SKU:
CAB17067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_066968.3).
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9988
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HT-29 cells, using DMTF1 Rabbit pAb (CAB17067) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
