DMTF1 Rabbit Polyclonal Antibody (CAB17067)
- SKU:
- CAB17067
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | DMTF1 Rabbit Polyclonal Antibody |
SKU: | CAB17067 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_066968.3). |
Sequence: | VTVQ CHTP RVII QTVA TEDI TSSI SQAE LTVD SDIQ SSDF PEPP DALE ADTF PDEI HHPK MTVE PSFN DAHV SKFS DQNS TELM NSVM VRTE EEIS DTDL KQEE SPSD LASA YVTE GLES PTIE EQVD QTID DETI LIVP SPHG FIQA SDVI DTES VLPL TTLT DPIL QHHQ EESN IIGS SLGS PVSE DSKD VEDL VNCH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DMP1; DMTF; MRUL; hDMP1; DMTF1 |
Positive Sample: | HT-29 |
Cellular Localization: | cytosol, nucleoplasm, nucleus |
Calculated MW: | 84kDa |
Observed MW: | 85kDa |
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9988 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |