The DMRT1 Polyclonal Antibody (CAB8411) is a valuable tool for researchers studying the DMRT1 gene, which plays a key role in sex determination and differentiation in animals. This antibody, produced in rabbits, is highly specific to DMRT1 and has been validated for use in applications such as Western blotting.DMRT1 is a transcription factor that is involved in the development of male sex organs and the maintenance of male characteristics in various species. Mutations in this gene have been linked to disorders of sexual development and infertility in humans and other animals. By using the DMRT1 Polyclonal Antibody, researchers can accurately detect and analyze DMRT1 expression in different tissues and cell types, providing insights into its function and potential therapeutic implications.
With its high reactivity and specificity for DMRT1, this antibody is an essential tool for studies exploring the molecular pathways and mechanisms underlying sex determination and reproductive biology. Its use in research may lead to a better understanding of genetic and hormonal factors that influence sexual development, offering new possibilities for the treatment of related conditions and disorders.
Product Name:
DMRT1 Rabbit Polyclonal Antibody
SKU:
CAB8411
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 134-373 of human DMRT1 (NP_068770.2).
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
Purification Method:
Affinity purification
Gene ID:
1761
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DMRT1 Rabbit pAb (CAB8411) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
