DMAP1 Rabbit Polyclonal Antibody (CAB2324)
- SKU:
- CAB2324
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Product Name: | DMAP1 Rabbit Polyclonal Antibody |
SKU: | CAB2324 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human DMAP1 (NP_061973.1). |
Sequence: | MATG ADVR DILE LGGP EGDA ASGT ISKK DIIN PDKK KSKK SSET LTFK RPEG MHRE VYAL LYSD KKDA PPLL PSDT GQGY RTVK AKLG SKKV RPWK WMPF TNPA RKDG AMFF HWRR AAEE GKDY PFAR FNKT VQVP VYSE QEYQ LYLH DDAW TKAE TDHL FDLS RRFD LRFV VIHD RYDH QQFK KRSV EDLK ERYY HICA KLAN VRAV PGTD LKIP VFDA GHER RRKE QLER LYNR TPEQ VAEE EYLL QELR KIEA RKKE REKR SQDL QKLI TAAD TTAE QRRT ERKA PKKK LPQK KEAE KPAV P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:4000 |
Synonyms: | EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1; DMAP1 |
Positive Sample: | SH-SY5Y,SW480,A375,HeLa,Jurkat,NIH/3T3,Mouse thymus,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 53kDa |
Observed MW: | 60kDa |
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Purification Method: | Affinity purification |
Gene ID: | 55929 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |