The DMAP1 Polyclonal Antibody (CAB2324) is a valuable tool for researchers studying DMAP1, a protein involved in transcription regulation and chromatin remodeling. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DMAP1 protein, this antibody allows for the detection and analysis of DMAP1 in various cell types, making it ideal for studies in molecular biology and cancer research.
DMAP1 plays a crucial role in gene expression regulation and is implicated in various cellular processes, including DNA repair and replication. Its involvement in chromatin remodeling also suggests its importance in controlling cell development and differentiation. Research on DMAP1 is essential for understanding the molecular mechanisms underlying cancer and other diseases, as well as for developing potential treatments targeting DMAP1-mediated pathways.
Product Name:
DMAP1 Rabbit Polyclonal Antibody
SKU:
CAB2324
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human DMAP1 (NP_061973.1).
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Purification Method:
Affinity purification
Gene ID:
55929
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DMAP1 antibody (CAB2324) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
