The DLX4 Antibody (PAC021918) is a powerful tool for researchers studying the DLX4 protein, a transcription factor involved in the regulation of gene expression during development. This antibody, produced and purified using advanced techniques, exhibits high specificity and sensitivity in a variety of applications.With its strong affinity for the DLX4 protein, this antibody enables precise detection and analysis of DLX4 in different cell types and tissues. Its reliability and consistency make it an essential reagent for studies in developmental biology, cancer research, and regenerative medicine.DLX4 is known to play a crucial role in the development of tissues and organs, making it a key target for investigating developmental disorders and congenital anomalies.
By elucidating the functions of DLX4, researchers can gain valuable insights into the molecular mechanisms underlying normal development and disease processes.Overall, the DLX4 Antibody (PAC021918) holds great promise for advancing our understanding of DLX4 biology and its implications for human health. Its exceptional performance and versatility make it a valuable asset for any laboratory conducting research in the field of developmental biology and beyond.
Antibody Name:
DLX4 Antibody (PACO21918)
Antibody SKU:
PACO21918
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from C-terminal of human DLX4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using DLX4 antibody.
Background:
May play a role in determining the production of hemoglobin S. May act as a repressor. Price J.A., Hum. Mol. Genet. 7:563-569(1998).
Synonyms:
Homeobox protein DLX-4; DLX-7; DLX-8; β protein 1;
UniProt Protein Function:
DLX4: May play a role in determining the production of hemoglobin S. May act as a repressor. Belongs to the distal-less homeobox family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.33
Molecular Function:protein binding; sequence-specific DNA binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter
NCBI Summary:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
