The DLL4 Polyclonal Antibody (CAB12943) is specifically designed for research involving DLL4, a cell surface ligand that plays a crucial role in regulating Notch signaling pathway, which is involved in cell fate determination and development. The antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DLL4 protein, this antibody allows for the detection and analysis of DLL4 in various cell types, making it an ideal tool for studies in developmental biology and cancer research.
DLL4 is known for its involvement in angiogenesis and vascular development, making it a potential therapeutic target for diseases like cancer and vascular disorders. The modulation of DLL4 signaling pathway has shown promise in inhibiting tumor growth and metastasis, making it a key focus in cancer research. Understanding the role of DLL4 in development and disease is essential for developing targeted therapies that can effectively modulate Notch signaling for therapeutic benefits.
Product Name:
DLL4 Rabbit Polyclonal Antibody
SKU:
CAB12943
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 317-530 of human DLL4 (NP_061947.1).
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
Purification Method:
Affinity purification
Gene ID:
54567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DLL4 Rabbit pAb (CAB12943) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
