The DLK1 Polyclonal Antibody (CAB6578) is a valuable tool for researchers studying DLK1, a transmembrane protein involved in various cellular processes, including differentiation, proliferation, and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to DLK1 protein, researchers can confidently detect and analyze DLK1 expression in different cell types, making it an essential component for studies in developmental biology and cancer research.
DLK1, also known as Delta-like 1 homolog, has been implicated in diverse physiological and pathological processes, such as stem cell renewal, adipogenesis, and tumorigenesis. Its role in regulating cell fate and tissue growth makes it a promising target for investigating conditions like diabetes, obesity, and various cancers. The DLK1 Polyclonal Antibody provides researchers with a powerful tool to gain insights into DLK1 function and explore its potential therapeutic applications in disease treatment.
Product Name:
DLK1 Rabbit Polyclonal Antibody
SKU:
CAB6578
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 83-383 of human DLK1 (NP_003827.3).
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.
Purification Method:
Affinity purification
Gene ID:
8788
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse heart, using DLK1 Rabbit pAb (CAB6578) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
