The DLG4 Polyclonal Antibody (CAB6194) is a valuable tool for researchers studying DLG4, a key protein involved in synaptic function and plasticity. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the DLG4 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in neuroscience and neurobiology.DLG4, also known as PSD-95, is a scaffolding protein essential for organizing synaptic proteins and maintaining synaptic structure. Its role in synaptic transmission and plasticity makes it a critical protein in understanding learning and memory processes.
Research on DLG4 helps to unravel the mechanisms underlying neurological disorders such as Alzheimer's disease, schizophrenia, and autism spectrum disorders.By utilizing the DLG4 Polyclonal Antibody, researchers can delve deeper into the functions and interactions of DLG4 in the brain, paving the way for potential therapeutic interventions targeting synaptic dysfunction and cognitive impairment. This antibody is a valuable tool for advancing our understanding of synaptic biology and its implications in neurological diseases.
Product Name:
PSD95 Rabbit Polyclonal Antibody
SKU:
CAB6194
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-510 of human PSD95 (NP_001308004.1).
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1742
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSD95 antibody (CAB6194) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
